Species Interactions and Comparative Immunology (SPICI)

We work on non-model invertebrates (worms) collected in Natura. Worms occupy a large range of habitats (terrestrial, marine…) including very extreme ones (highly polluted estuaries, hydrothermal vents, polar, abyssal…) and show impressive capacities of body regeneration. As a probable consequence, they constitute a source of a large variety of atypical and multifunctional AMPs. Concretely, our group isolates /identifies new AMPs in worms, studies their multifunctions (antibacterial, neurotrophic, regenerative, symbiostasis, transgenerational transfer of immunity…) and uses them as markers to follow the immune adaptation and acclimation to changing abiotic and biotic conditions.

Our actual and recent questions are: What is the nature of the AMPs produced by animals able to thrive in harsh conditions? What are the patterns of selection and expression of AMP genes in metazoans exposed to abiotic and biotic environmental pressures? Do and how AMPs participate in controlling and shaping the establishment of detoxifying microbial symbiosis that are vital to face extreme conditions? Does and how the mother use the selected AMPs to transmit her environmental experience to her offspring?

Equipe « Species Interactions and Comparative Immunology (SPICI)»

Resp. de l’équipe : Aurélie Tasiemski

Correspondant GDR : Aurélie Tasiemski, aurelie.tasiemski@univ-lille1.fr

Adresse complète

Université de Lille1, cité scientifique, bâtiment SN2, 59655

Villeneuve d’Ascq

Code unité

UMR 8198

Tutelle(s)

CNRS-Université de Lille

Adresse internet du laboratoire ou institut

http://spici.weebly.com/

Antagonistic evolution of an antibiotic and its molecular chaperone: How to maintain a vital ectosymbiosis in a highly fluctuating habitat

Claire Papot, françois Massol, Didier Jollivet, Aurélie Tasiemski: Antagonistic evolution of an antibiotic and its molecular chaperone: How to maintain a vital ectosymbiosis in a highly fluctuating habitat. Scientific Reports 05/2017; 7(1)., DOI:10.1038/s41598-017-01626-2

Life history and eco-evolutionary dynamics in light of the gut microbiota

Emilie Macke, Aurélie Tasiemski, François Massol, Martijn Callens, Ellen Decaestecker: Life history and eco-evolutionary dynamics in light of the gut microbiota. Oikos 04/2017; 126(4):508- 531., DOI:10.1111/oik.03900

Neuro-immune lessons from an annelid: The medicinal leech.

Aurélie Tasiemski, Michel Salzet: Neuro-immune lessons from an annelid: The medicinal leech. Developmental and comparative immunology 07/2016; 66., DOI:10.1016/j.dci.2016.06.026

Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verban

Aurélie Tasiemski, Francois Massol, Virginie Cuvillier, Celine Boidin-Wichlacz, Emmanuel Roger, Franck Rodet, Isabelle Fournier, Frédéric Thomas, Michel Salzet: Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii. Scientific Reports 10/2015; 5., DOI:10.1038/srep17498

Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana

Aurélie A Tasiemski, Sascha Jung, Céline Boidin-Wichlacz, Didier Jollivet, Virginie Cuvillier- Hot, Florence Pradillon, Costantino Vetriani, Oliver Hecht, Frank D Sönnichsen, Christoph Gelhaus, Chien-Wen Hung, Andreas Tholey, Matthias Leippe, Joachim Grötzinger, Françoise Gaill: Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana. PLoS ONE 04/2014; 9(4):e95737., DOI:10.1371/journal.pone.0095737

Impact of ecological doses of the most widespread phthalate on a terrestrial species, the ant Lasius niger

Virginie Cuvillier-Hot, Karine Salin, Séverine Devers, Aurélie Tasiemski, Pauline Schaffner, Raphaël Boulay, Sylvain Billiard, Alain Lenoir: Impact of ecological doses of the most widespread phthalate on a terrestrial species, the ant Lasius niger. Environmental Research 04/2014; 131C:104-110., DOI:10.1016/j.envres.2014.03.016

Polychaetes as annelid models to study ecoimmunology of marine organisms

Virginie Cuvillier-Hot, Céline Boidin-Wichlacz, Aurélie A Tasiemski: Polychaetes as annelid models to study ecoimmunology of marine organisms. Journal of Marine Science and Technology 03/2014; 22(1):9-14., DOI:10.6119/JMST-013-0718-1

Macin Family of Antimicrobial Proteins Combines Antimicrobial and Nerve Repair Activities

Sascha Jung, Frank D Sönnichsen, Chien-Wen Hung, Andreas Tholey, Céline Boidin-Wichlacz, Wiebke Haeusgen, Christoph Gelhaus, Christine Desel, Rainer Podschun, Vicki Waetzig, Aurélie Tasiemski, Matthias Leippe, Joachim Grötzinger: Macin Family of Antimicrobial Proteins Combines Antimicrobial and Nerve Repair Activities. Journal of Biological Chemistry 03/2012; 287(17):14246-58., DOI:10.1074/jbc.M111.336495

Morphological and functional characterization of leech circulating blood cells: Role in immunity and neural repair

Céline Boidin-Wichlacz, David Vergote, Christian Slomianny, Nathalie Jouy, Michel Salzet, Aurélie Tasiemski: Morphological and functional characterization of leech circulating blood cells: Role in immunity and neural repair. Cellular and Molecular Life Sciences CMLS 12/2011; 69(10):1717-31., DOI:10.1007/s00018-011-0897-x

Multiple Changes in Peptide and Lipid Expression Associated with Regeneration in the Nervous System of the Medicinal Leech

Céline Meriaux, Karim Arafah, Aurélie Tasiemski, Maxence Wisztorski, Jocelyne Bruand, Céline Boidin-Wichlacz, Annie Desmons, Delphine Debois, Olivier Laprévote, Alain Brunelle, Terry Gaasterland, Eduardo Macagno, Isabelle Fournier, Michel Salzet: Multiple Changes in Peptide and Lipid Expression Associated with Regeneration in the Nervous System of the Medicinal Leech. PLoS ONE 04/2011; 6(4):e18359., DOI:10.1371/journal.pone.0018359

Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes.

Eduardo R Macagno, Terry Gaasterland, Lee Edsall, Vineet Bafna, Marcelo B Soares, Todd Scheetz, Thomas Casavant, Corinne Da Silva, Patrick Wincker, Aurélie Tasiemski, Michel Salzet: Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes. BMC Genomics 06/2010; 11(1):407., DOI:10.1186/1471-2164-11-407

Leech Immunity: From Brain to Peripheral Responses

Aurélie Tasiemski, Michel Salzet: Leech Immunity: From Brain to Peripheral Responses. Advances in Experimental Medicine and Biology 01/2010; 708:80-104., DOI:10.1007/978-1- 4419-8059-5_5

Microbial Challenge Promotes the Regenerative Process of the Injured Central Nervous System of the Medicinal Leech by Inducing the Synthesis of Antimicrobial Peptides in Neurons and Microglia

David Schikorski, Virginie Cuvillier-Hot, Matthias Leippe, Céline Boidin-Wichlacz, Christian Slomianny, Eduardo Macagno, Michel Salzet, Aurélie Tasiemski: Microbial Challenge Promotes the Regenerative Process of the Injured Central Nervous System of the Medicinal Leech by Inducing the Synthesis of Antimicrobial Peptides in Neurons and Microglia. The Journal of Immunology 08/2008; 181(2):1083-95., DOI:10.4049/jimmunol.181.2.1083

A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor

Aurélie Tasiemski, David Schikorski, Françoise Le Marrec-Croq, Christelle Pontoire-Van Camp, Céline Boidin-Wichlacz, Pierre-Eric Sautière: Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor. Developmental & Comparative Immunology 02/2007; 31(8):749-62., DOI:10.1016/j.dci.2006.11.003

Innate Immunity in Lophotrochozoans: The Annelids

Michel Salzet, Aurélie Tasiemski, Edwin Cooper: Innate Immunity in Lophotrochozoans: The Annelids. Current Pharmaceutical Design 02/2006; 12(24):3043-50., DOI:10.2174/138161206777947551

Molecular Characterization of Two Novel Antibacterial Peptides Inducible upon Bacterial Challenge in an Annelid, the Leech Theromyzon tessulatum

Aurélie Tasiemski, Franck Vandenbulcke, Guillaume Mitta, Jérôme Lemoine, Christophe Lefebvre, Pierre-Eric Sautière, Michel Salzet: Molecular Characterization of Two Novel Antibacterial Peptides Inducible upon Bacterial Challenge in an Annelid, the Leech Theromyzon tessulatum. Journal of Biological Chemistry 08/2004; 279(30):30973-82., DOI:10.1074/jbc.M312156200

Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides

Aurélie Tasiemski, Hamida Hammad, Franck Vandenbulcke, Christophe Breton, Thomas J Bilfinger, Joel Pestel, Michel Salzet: Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides. Blood 08/2002; 100(2):553-9., DOI:10.1182/blood.V100.2.553

nvolvement of pro-enkephain-derived peptides in immunity

M Salzet, A Tasiemski: Involvement of pro-enkephain-derived peptides in immunity. Developmental & Comparative Immunology 05/2001; 25(3):177-85., DOI:10.1016/S0145- 305X(00)00047-1

The presence of antibacterial and opioid peptides in human plasma during coronary artery bypass surgery

Aurelie Tasiemski, Michel Salzet, Herbert Benson, Gregory L Fricchione, Thomas V Bilfinger, Yannick Goumon, Marie Helene Metz-Boutigue, Dominique Aunis, George B Stefano: The presence of antibacterial and opioid peptides in human plasma during coronary artery bypass surgery. Journal of Neuroimmunology 10/2000; 109(2):228-35., DOI:10.1016/S0165- 5728(00)00314-3

Proenkephalin A-derived peptides in invertebrate innate immune processes

Aurélie Tasiemski, Martine Verger-Bocquet, Mario Cadet, Yannick Goumon, M H Metz- Boutigue, Dominique Aunis, George B Stefano, Michel Salzet: Proenkephalin A-derived peptides in invertebrate innate immune processes. Molecular Brain Research 04/2000; 76(2):237-52., DOI:10.1016/S0169-328X(00)00005-X

Purification, identification, tests biologiques (antimicrobiens, chimioattraction, régénération), immunohisto et cyto-chimie, évolution (patrons de sélection) et modalités d’expression des gènes.

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